Effect of nitric oxide synthase inhibitors on the changes of hemodynamic parameters and aortic tension induced by septic shock in rats

Abstract

In this study, we investigated the effect of three types of nitric oxide synthase inhibitors on the changes of hemodynamic parameters and thoracic aorta tension induced by septic shock in rats. We established the septic shock model rats by Cecal ligation and puncture (CLP), and nitric oxide synthase inhibitors (L-NAME, AMG and 7-NI) were injected after CLP. Mean arterial blood pressure (MABP), and ventricular dynamic parameters (heart rate, left ventricular developed pressure, maximal rise/fall velocity of ventricular pressure) were monitored. Isolated thoracic rings were mounted on an organ bath and the tension of the vessel was recorded. Results shown that after using L-NAME, AMG and 7-NI the mortality decreased to 50.0%, 37.5%, and 42.1%; MABP and ventricular dynamic parameters were decreased. The three types of nitric oxide synthase inhibitors can improve the hemodynamic parameters and vasoconstriction responsiveness of endothelium-denuded aorta of septic shock rats.