Abstract
The influence of nilvadipine, a novel calcium channel antagonist on adrenal regeneration was investigated in male Wistar rats. The estimation of the mitotic index after administration of colchicine was supplemented by an immunoperoxidase technique with monoclonal antibodies to bromodeoxyuridine. Plasma corticosterone was determined by a radioimmunological assay. Nilvadipine was given subcutaneously in two doses (0.2 and 1 mg/kg) to animals subjected to adrenal enucleation combined with contralateral adrenalectomy. It was found that nilvadipine inhibited the proliferation ratio of adrenocortical cells on the 4th day after surgery in a dose-dependent manner. The inhibitory effect of nilvadipine became less significant by 8 days after operation. However, no changes in corticosterone secretion were observed.
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Schedule a callMore From: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
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