Abstract
Nigericin, a carboxylic movovalent cation ionophore, induced opacification in the rabbit lens within 2 hr of incubation at 37°C at a concentration of 10 −7 m. The opacification was in the subcapsular region where a marked degree of Ca 2+ accumulation and change in the monovalent cation balance occurred. Nigericin may accumulate and act locally at the surface region of the lens, presumably due to the high lipid solubility of nigericin. Nigericin induced an opacification of the lens when applied either to the anterior chamber or to the vitreous of rabbit eye.
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