Abstract
Background: Nigella sativa (NS) (black seed) and Bee's honey (BH) are relatively cheap and safe natural products with anti-inflammatory and antiallergic properties. They are used traditionally in the treatment of so many diseases. Objective: The objective was to investigate the adjuvant effect of combined use of NS and BH with the inhaled corticosteroids (ICS) on respiratory rate (RR), pulse rate (PR), blood pressure (BP), oxygen saturation (SPO 2 ), and wheezing symptom in patients with moderate and severe persistent asthma. Materials and Methods: An oral dose of NS (2 mg once daily) and BH (7.5 ml twice a day) was given for 3 months. Proper chest examination, the vital signs (RR, PR, and BP) and standard measurement of SPO 2 were performed initially (baseline) and at the end of the 3 rd month. Results: Totally, 30 asthmatic patients were included (14 females and 16 males), aged 16-50 years with a mean age of 43.91 5.8. By the end of the 3 rd month: The RR, PR, systolic BP, and diastolic BP were significantly decreased ( P 2 was increased, and wheezing was significantly reduced in both asthma categories. Conclusion: Combination of NS and BH as an adjuvant therapy with ICS was found to improve the cardiopulmonary functions and helps better control of asthma symptoms.
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