Abstract

To determine the efficacy of nicotinic acid on the lipid profile of diabetic and non diabetic rats. This was an experimental study done at the Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan between May 2010 to July 2010. Nicotinic acid was administered to a hypercholesterolemic group and a hypercholesterolemic + diabetic Group of Albino rats for 42 days and response to therapy was recorded on day 21 and day 42 of the experiment. Comparison among these two groups as well as three control groups was determined by Analysis of Variance (ANOVA) and differences were considered significant at (P<0.05). A total of 50 rats were included in the study. Lipid profile of the hypercholesterolemic group as well as hypercholesterolemic + diabetic group as compared with the control groups showed highly significant improvement on the day 21 and day 42 of the experiment. The values of serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) cholesterol and total lipids (TL) showed highly significant decrease whereas serum high density lipoprotein (HDL) cholesterol showed highly significant increase. Nicotinic acid is the most effective agent available in increasing HDL cholesterol and lowering serum TC, triglycerides (TG), LDL cholesterol and TL in hypercholesterolemic Diabetic and hypercholesterolemic non-diabetic Albino rats.

Highlights

  • Niacin or nicotinic acid can serve as a wonder drug for correcting lipid metabolic disorders besides it functions as a B group vitamin

  • It was seen that after 42 days of treatment with Nicotinic Acid Total Cholesterol (TC) of group 4 decreased from 213 ± 3.02 mg/dl to 149 ± 3.86 mg/ dl which is highly significant (P

  • Total Cholesterol of Group 5 decreased from 217 ± 3.33 mg/dl to 161 ± 1.63 mg/dl which is highly significant as (P

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Summary

Introduction

Niacin or nicotinic acid can serve as a wonder drug for correcting lipid metabolic disorders besides it functions as a B group vitamin. It is a water soluble vitamin and has since long been used to treat lipid disorders, which, if left untreated, would result in atherosclerosis and cardiovascular problems. It has remarkable HDL cholesterol raising capability. It lowers the bad cholesterol, that, is very low density lipoprotein (VLDL) and LDL as well as TG and fatty acids.[1] Biochemically, nicotinic acid is a derivative of Pyridine, a pyridine-3-carboxylic acid. The mechanism of action has only been recently made clear

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