Abstract
IN 1955, Altschul et al. reported1 that large doses of nicotinic acid, but not of its amide, decreased serum cholesterol-levels in man and rabbit. This finding has been confirmed by many workers2. Despite several investigations of mechanisms, however, the locus of the nicotinic acid effect remains unknown3,4. We wish to report an effect of high concentrations of nicotinic acid on sterol biosynthesis in yeast. This effect may account for the hypocholesteremic action of nicotinic acid.
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