Effect of Newly Synthesized Polypropylene/Silver Nonwoven Fabric Dressing on Incisional Wound Healing in Rats

Abstract

AIM: The present work aimed to investigate the effect of the antimicrobial nano Ag/polypropylene (PP\Ag) dressing on incisional wound healing on the experimental level.MATERIALS AND METHODS: Male albino rats were divided into, control, PP/Ag dressing, Silver Sulfadiazine (Ag-SD) cream, blank PP dressing and undressed groups. Animals were sacrificed after 5, 10 and 15 days of incisional wound event.RESULTS: Reduction was found in incision wound length in PP/Ag dressed rats, Ag-SD cream treated rats, and blank PP dressed rats after 5, 10 and 15 days compared to undressed rats. Skin of PP/Ag group showed less adverse histopathological changes, enhanced granulation tissue formation, enhanced angiogenesis, accelerated re-epithelialization and quick complete healing; compared to all other groups. Significant decrease in TGF-β level was recorded in PP\Ag and Ag-SD cream groups as compared to blank PP group on day 5. While, significant decrease in TGF-β level was detected in PP\Ag group when compared with undressed and blank PP groups on day 10. TGF-β showed significant in PP\Ag group as compared to undressed, Ag-SD cream and blank PP groups on day 15. CONCLUSION: The present results suggest that PP/Ag dressing enhances, promotes and plays an important role in wound healing.