Abstract
The transient rise in plasma citrate which occurs after nephrectomy was studied in rats by measuring plasma citrate concentrations and the rate of conversion of intravenously administered C14-labeled citrate to respiratory CO2. Two hours after nephrectomy plasma citrate was greatly elevated and the rate of oxidation of radioactive citrate was slow. Twenty-four hours after nephrectomy both plasma citrate and rate of oxidation of labeled citrate were normal. In a parathyroidectomized rat in which little rise in plasma citrate followed nephrectomy the rate of conversion of radioactive citrate to CO2 was almost normal. Injection of a large intraperitoneal dose of citrate before administering C14-labeled citrate resulted in a delayed recovery of respiratory C14O2. These results indicate that no decrease in the rate of oxidation of plasma citrate occurs after nephrectomy and that nonrenal tissues are able to metabolize circulating citrate at a substantial rate. Consequently the rise in plasma citrate after nephrectomy probably is due to a temporary increase in the rate of production of plasma citrate rather than to a decrease in the rate of citrate oxidation.
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