Effect of nepafenac on the foveal profile of glaucomatous patients undergoing phacoemulsification.

Abstract

Retrospective, pilot study to determine whether nepafenac treatment pre- and postcataract surgery in glaucoma patients using topical hypotensive agents minimized cystoid macular edema by comparing pre- and postsurgical foveal characteristics, as in some cases these agents cannot be withdrawn and, hypothetically, their inflammatory effect on the fovea could be neutralized by the addition of nepafenac. Patients were divided into two subgroups depending on whether or not topical nepafenac was added to the surgical protocol (NEP=nepafenac group and nNEP=non nepafenac group). All had undergone phacoemulsification and data on pre- and postoperative macular status were recorded. In the nNEP group, there was a significant increase in foveal thickness (FT) in the first month postoperative visit with respect to the preoperative status (p=0.006), and this situation did not change at the third postoperative month (p=0.9411). In the NEP group, the increase in FT was not significant at the first month after surgery (p=0.056) nor at the final visit (p=0.268), in contrast to the nNEP group. This study of the possible prophylactic effect of nepafenac on postoperative macular edema supports the results of other studies that confirm subclinical edema post phacoemulsification, and found a significantly lower gradient in the increase in FT in patients treated pre- and postoperatively with nepafenac.