Effect of Neonatal Hyperbilirubinemia on Ventricular Functions

Abstract

Background: Unconjugated hyperbilirubinemia(UCH) is a common systemic disease in the neonate. Many researches on etiology, risk factors and treatment have been made and guidelines have been drawn up. Because it is a systemic disease, it affects the body, organelle, cells, organs and systems. Researchers have also done a lot of research to clarify which levels, which mechanisms, and which organs the unkonjuge bilirubin affects. We aimed to investigate the effect of high unconjugated bilirubin levels on left and right ventricular systolic and diastolic functions in newborns by echocardiography and doppler. Methods: This single-center, prospective, case-control study was conducted on 19 full-term newborn infants with severe UHB requiring phototherapy and 20 healthy infants as controls. Ventrikuler fonction assessment was performed by using M-mode ekokardiyografi and doppler. Results: There was no significant difference in right and left ventriculer fonctions between two groups. Conclusions: In our study, unkonjugated hyperbilirubinemia did not affect left and right ventricular function. However, we believe that new studies are needed with higher bilirubin values and wider case groups.