Abstract
The left ear of newborn guinea pigs was closed by removing the skin and cartilage of the external auditory meatus and pulling the surrounding tissue over the opening with silk sutures. At 60 days of age the animals were anesthetized with chloral hydrate and auditory brainstem responses (ABR) were measured before and after destroying the intact right ear. After ABR testing the animals were killed and their cochleas were examined histologically. Right and left brainstems were embedded in paraffin, serially sectioned and stained with cresyl violet. The cross‐sectional area of four different cell types was measured, using a total of 210 cells of each type from each side. For all four groups; large spherical cells, small spherical cells, pale globular cells, and octopus cells, soma size was significantly smaller (P < 0.01) on the left side. This result for guinea pigs, a precocial animal, agrees with earlier findings for an altrical animal the mouse [D. B. Webster, Exp. Neurol. 79, 130–140 (1983)]. [Supported by NIH training grant NSD‐07058 and the Louisiana Lions Eye Foundation.] Present address: Dept. of Biological Sciences, Loyola University, New Orleans, LA 70118.
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