Abstract
Summary1) Neomycin was given orally to 18 patients at daily dose of 1.5 to 2 g for 4 to 20 weeks. Mean serum cholesterol levels were decreased significantly in each patient by 17 to 29%, and were maintained low for duration of administration of neomycin. Average fall for the group was 21%. Intramuscular administration of neomycin to 5 patients for 3 weeks failed to alter serum cholesterol levels. 2) Oral administration of 12 g of para-aminosalicylic-acid to 2 patients lowered serum cholesterol concentrations significantly in each, while the daily dose of 6 g had no effect on serum cholesterol levels. 3) When phthalylsulfathiazole, isoniazid, dihydrostreptomycin, oxytetracycline, polymyxin B sulfate, bacitracin and novobiocin were given orally, no appreciable changes in serum cholesterol concentration resulted.
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