Effect of neoadjuvant chemotherapy on serum tumor markers and survival time in patients with epithelial ovarian cancer

Abstract

Objective To investigate the effect of neoadjuvant chemotherapy (NAC) on serum tumor markers and survival time in patients with epithelial ovarian cancer. Methods Ninety cases of epithelial ovarian cancer in the Central Hospital of Yuncheng from March 2014 to June 2015 were selected as the research subjects and were divided into control group and observation group according to the random number table method, with 45 cases in each group. The control group was treated with routine postoperative chemotherapy, and the observation group was treated with NAC on the basis of the control group. The clinical effects, the levels of serum tumor markers and the patient’s survival time were compared between the two groups. Results The effective rate of treatment and the rate of disease control were higher in the observation group than those in the control group(P<0.05). After treatment, the levels of cancer antigen (CEA), cancer antigen (CA125) and human epididymis protein 4 (HE4) were significantly lower than those before treatment, and the improvement of the above indexes in the observation group was better than that of the control group (P<0.05), the 1-year survival rate, 2-year survival rate and 3-year survival rate in the observation group were significantly higher than those in the control group(P<0.05). Conclusions NAC can improve the clinical efficacy on advanced epithelial ovarian cancer, and reduce the content of serum CEA, CA125, HE4 tumor markers and improve the survival rate of patients. It is worth popularizing in clinics. Key words: Epithelial ovarian cancer; Neoadjuvant chemotherapy; Tumor marker; Survival time