Abstract
Suppression of apoptosis is responsible for epidermal thickness in psoriasis. Survivin is an anti-apoptotic protein that can be modulated by ultraviolet B (UVB). Our aim was to investigate the role of survivin in psoriasis and to evaluate the effect of narrow band (NB)-UVB on the survivin levels in psoriatic lesions. This study included 20 psoriatic patients and 20 healthy controls. Patients were treated with 24 sessions of NB-UVB. Skin biopsies were taken from the affected skin of each patient before and after treatment, and from the controls, to examine survivin levels by ELISA. Survivin was significantly upregulated in psoriasis compared to controls (p<0.001). We found significant positive correlations between survivin levels before therapy and the extent of body involvement (r=0.675, p=0.002), as well as the PASI score (r=0.67, p=0.001). A significant decrease in survivin levels was observed post treatment compared to baseline levels (p<0.001). We found increased survivin levels in psoriasis and a significant reduction following NB-UVB induced clinical improvement of psoriasis.
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