Abstract
The effectiveness of naloxone in blocking biochemical changes associated with morphine addiction was investigated. Concomitant administration of naloxone with morphine over a 9-day period successfully blocked the suppressive action of morphine on plasma ACTH and corticosterone and the enhancing effect of it on cyclic-GMP. In view of naloxone's ability to competitively block the binding of morphine at opiate receptors, it is suggested that the events leading to the above biochemical changes are initiated at these sites.
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