Abstract
Bacteriophages treated with NaClO 4 release their DNA. The rate of release depends upon NaClO 4 concentration and varies with phage type. There are apparently two mechanisms of release: (1) at low perchlorate concentrations the DNA is injected through the phage tail; (2) at high concentration the phage head is disrupted. For several phages examined only 50% of the particles will release by the injection mechanism. It has also been found that in some situations the DNA is injected but remains attached to the phage ghost by means of an unknown bond which is thermally labile and broken by high perchlorate concentrations. In all cases the perchloratereleased DNA is indistinguishable from DNA released by more standard methods.
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