Abstract
SummaryThe effect of N-γ-phenylpropyl-N-benzyloxy acetamide (W-1372) upon the establishment and progression of atheromata in cholesterol-fed rabbits has been investigated. At a level of 2% in the diet W-1372 inhibits weight gain and does not affect serum cholesterol levels but raises serum triglyceride levels. Liver cholesterol levels are significantly lower in rabbits fed W-1372. The average atheromata in the aortic arch and thoracic aorta of rabbits fed an atherogenic regimen augmented with 2% W-1372 are significantly lower than those observed in controls. When W-1372 (2%) is fed to rabbits with preestablished atheromata for 2 months, the exacerbation of severity of lesions is reduced when compared to controls. Atheromata in the aortic arch are 11% less severe and in the thoracic aorta 30% less severe.
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