Abstract
BackgroundComminuted fractures can occur due to severe traumas. The treatment of these fractures that may cause serious morbidity and sometimes mortality is N-butyl cyanoacrylate. It has been reported that this adhesive provides sufficient rigid fixation for bone healing. This study aims to examine cyanoacrylate radiologically and histologically to determine whether it provides adequate recovery in segmental fractures. The secondary objective is to evaluate N-butyl cyanoacrylate, an adhesive material that can hold the fragments on the fracture line together following reduction.MethodsSixteen Sprague–Dawley rats were divided in two groups as control (n = 8) and experimental (n = 8) groups. In the control group, segmental fractures were made and fixated with K-wire. In the experimental group, the same surgical procedure was applied and also fragments were stabilized with N-butyl cyanoacrylate.ResultsOn the sixth week, we did not see any statistically significant difference in the radiological scoring between groups. However, the pathological scores of the control group were statistically higher than the cyanoacrylate group.ConclusionsWe found that cyanoacrylate was rapidly and easily applied in the segmental fractures but did not cause any superior radiological and clinical results compared to the control group. The cyanoacrylate had low viscosity, and it was not capable enough to fill the defects formed between osteotomy surfaces. However, it did not adversely affect fracture healing as seen in biopsies taken as a result of follow-ups.
Highlights
Numerous fixation methods have been devised to treat bone fractures, the search for optimal fixation methods continues
They have stated that ethyl cyanoacrylate and 2-octyl-cyanocrylate did not allow for graft incorporation, producing a localized and discrete inflammatory reaction which persisted at 60 days, being more intense in the octyl cyanoacrylate group [9]
The researchers indicated that radiological recovery was present on weeks 3 and 6, and the assessment of the statistical consistency among three independent researchers (IRs) indicated that they were all consistent
Summary
Numerous fixation methods have been devised to treat bone fractures, the search for optimal fixation methods continues. N-butyl cyanoacrylate is reported in the literature that it is a polymeric, strong adhesive for the skin, soft tissues, and bones and that it does not cause a significant inflammatory response and does not compromise recovery [2,3]. Esteves et al analyzed the repair process of an autogenous bone graft in a block fixed with ethyl cyanoacrylate and 2-octylcyanocrylate adhesives in rat calvaria. It has been reported that the use of cyanoacrylate adhesives does not hinder the vascularization of newly formed bone [10]. Comminuted fractures can occur due to severe traumas The treatment of these fractures that may cause serious morbidity and sometimes mortality is N-butyl cyanoacrylate. This study aims to examine cyanoacrylate radiologically and histologically to determine whether it provides adequate recovery in segmental fractures. The secondary objective is to evaluate N-butyl cyanoacrylate, an adhesive material that can hold the fragments on the fracture line together following reduction
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