Abstract
The interaction of |C n H 2 n+1 N +(CH 3) 3| · I − ( n = 3, 6, 9, 12, 14, 16 or 18) with egg-yolk phosphatidylcholine-water dispersions has been studied by 31P-NMR spectroscopy. It is shown that the effective anisotropy of 31P chemical shift (− Δσ eff) of the lamellar phospholipid liquid-crystalline phase L α increases with increasing concentration and alkyl chain length of the drug. Addition of | C 6 H 13 N +(CH 3) 3| ·I − or |C 9H 19N +(CH 3) 3|· I − to the phospholipid-water dispersion at a molar ratio ammonium salt:phospholipid > 0.8 induces in the dispersion a structure with an effective isotropic phospholipid motion. This structure is unstable and slowly transforms into the hexagonal phase. These effects have not been observed in phospholipid-water dispersions mixed with the ammonium derivatives with the longer alkyl chains n 12, 14, 16 or 18. It is proposed that these results might explain the effects of the investigated drugs on the nerve, muscle and bacterial cells.
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