Abstract
Cyclophosphamide (CPA)-induced bladder toxicity and lethality were inhibited by N-acetylcysteine (NAC) when given systemically at a 4 : 1 ratio prior to CPA. This dose of NAC did not affect the production or the formation of free alkylating agents from CPA in vivo or in vitro. The immunosuppressive effect of CPA against T cell response systems, such as graft vs host reaction, antibody to sheep red blood cells and (PHA) phytohemagglutin stimulation was unaffected by NAC. It is concluded that the metabolic products of CPA for cytotoxicity as expressed as cystitis and lethality are different from the alkylating agents, which appear to affect immunological phenomena.
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