Effect of Myristica fragrans extract on total body composition in cafeteria diet induced obese rats.

Vangoori Yakaiah

doi:10.6026/97320630015657

Abstract

It is of interest to evaluate the effect of Myristica fragrans on body composition of cafeteria diet induced obese rats. Thirty rats (150-160g) grouped into 5 and each group contains 6 rats. Group-1 was normal control and 2-5 groups were fed with cafeteria diet for 15 weeks to induce obesity. From 16th week to 25th week test drugs were given as mentioned in the experimental protocol. Body weight, BMI, changes in body composition was measured by TOBEC, adipose tissue weights, organ weights, abdominal circumference were measured according to standard methods. After 70days of treatment with MFE 200mg/kg, 400mg/kg Body weight reduced by 9.29%, 12.87% respectively. BMI was also decreased. Abdominal circumference, total fat percentage, organ weights, was substantially reduced. At 400mg/kg of MFE has shown maximum potentiality when compared with 200mg/kg. Orlistat 50mg was used as standard drug. Tetrahydrofuran, flavonoids, saponins, present in Myristica fragrans has shown anti obesity activity. Our findings explain the potentiality of phytochemicals as a potent anti obesity agent, provide scientific evidence for its traditional use and suggest the possible mechanism of action.

Highlights

Obesity is one of the biggest problems in developed and developing countries because of urbanisation and sedentary life style
Body mass index (BMI), changes in body composition was measured by total body electrical conductivity (TOBEC), adipose tissue weights, organ weights, abdominal circumference were measured according to standard methods
Morphological Parameters of Obesity: The obesity and body composition was assessed by evaluation of morphological parameters (Body weight, percentage of difference in body weight, BMI, Abdominal circumference, total body scanning, organ and fat pad weight (Epididymal, Mesenteric and Retroperitoneal fats), Adiposity index), was determined

Summary

Introduction

Obesity is one of the biggest problems in developed and developing countries because of urbanisation and sedentary life style. The rapid increase in the incidence of obesity during only the past few generations is primarily attributed to excessive consumption of palatable energydense foods which are high in saturated fats, refined sugars and sodium, combined with sedentary lifestyles [6]. The use of anti obesity drugs to reduce body weight has gained attention in recent years by decreasing the consumption or absorption of food or by increasing energy expenditure [7]. The available anti obesity medications like Sibutramine cause undesirable side effects including heart related complications, hypertension, constipation, psychiatric side effects. Orlistat is another drug approved by FDA for long term management of weight loss.

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