Abstract
Background: Parkinson’s disease (PD) is a neurodegenerative disorder having no permanent cure, but there has been a great deal of interest in finding the role of complementary and alternative medicines for the treatment of neurodegenerative disorders. Oxidative stress has also been implicated in the progression of PD. Objective: Since ancient time, natural plant products have been studied for their protective action. In this study, the effect of myricetin was studied on transgenic flies expressing human alpha-synuclein in the neurons. Materials and Methods: The PD flies were allowed to feed on a diet supplemented with 5, 10, and 20 μM of myricetin for 24 days. The flies with PD were then subjected to the study of oxidative stress markers. Results: The results of this study reveal that the exposure of flies with PD to myricetin showed a significant dose-dependent decrease in oxidative stress compared to unexposed flies with PD (P < 0.005). Conclusion: Myricetin is potent in reducing oxidative stress in the brain of flies with PD induced by the expression of human alpha-synuclein and the formation of Lewy bodies.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Nutrition, Pharmacology, Neurological Diseases
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
