Effect of myocardial ischemia on cardiac troponin I and T

Abstract

A substantial percentage of patients who have clinical unstable angina also have evidence of myocardial injury. 1 Ottani F Galvani M Nicolini F.A Ferrini D Pozzati A Di Pasquale G Jaffe A.S Elevated cardiac troponin levels predict the risk of adverse outcome in patients with acute coronary syndromes. Am Heart J. 2000; 140: 917-927 Abstract Full Text Full Text PDF PubMed Scopus (220) Google Scholar Many advocate that these patients should be diagnosed with acute myocardial infarction. 2 ESC/ACC CommitteeMyocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000; 36: 959-969 Abstract Full Text Full Text PDF PubMed Scopus (3772) Google Scholar , 3 Jaffe A.S Ravkilde J Roberts R Naslund U Apple F.S Galvani M Katus H It’s time for a change to a troponin standard. Circulation. 2000; 102: 1216-1220 Crossref PubMed Scopus (563) Google Scholar Clinicians faced with this prospect are unsure whether the release of troponin indicates myocardial injury or if it could occur with myocardial ischemia alone. 4 Wu A.H Ford L Release of cardiac troponin in acute coronary syndromes ischemia or necrosis?. Clin Chim Acta. 1999; 284: 161-174 Crossref PubMed Scopus (150) Google Scholar , 5 Sobel B.E LeWinter M.M Ingenuous interpretation of elevated blood levels of macromolecular markers of myocardial injury a recipe for confusion. J Am Coll Cardiol. 2000; 35: 1355-1358 Abstract Full Text Full Text PDF PubMed Scopus (42) Google Scholar