Effect of music therapy on physiology and anxiety state in the mechanical ventilation patients：a Meta-analysis

Abstract

Objective To systematically review the effect of the music therapy on physiology and anxiety state in the mechanical ventilation patients .Methods The databases including the PubMed , Cochrane Library, EMbase, Google, CBM, VIP, CNKI, EMbase and WanFang Data were searched from January 1998 to June 2013.The randomized controlled trails （RCTs） of the music therapy on physiology and anxiety state in the mechanical ventilation patients were chosen , and at the same time the related references in the literatures were also searched .The literatures were chosen according to the determined criteria , and the literature quality was assessed by the GRADEprofiler3.6 recommended by the GRADE system.The data was collected, and the Meta-analysis was carried out through the RevMan 5.2.Results A total of seven studies were included in this analysis.The analysis showed that the differences were found in the heart rate , respiration, systolic blood pressure and anxiety state between two groups after the intervention [WMD（95%CI） =-4.08（ -5.36,-2.79）,-2.50（-3.06,-1.94）,-5.45（ -9.52,-1.38）,-0.66（ -1.24,-0.07）, respectively], and no differences were found in the diastolic blood pressure and blood oxygen saturation [WMD（95%CI） =-1.76（-5.65,2.13）,-0.01 （ -3.53,3.51）, respectively].Conclusions The music therapy can effectively improve the heart rate , respiration, systolic blood pressure and anxiety state in the patients , and the effects on diastolic blood pressure and blood oxygen saturation in the patients are not significant .The large-sample, high-quality and standard RCTs should be further carry out so as to test the effect of music therapy in view of the low methodological quality in some included studies . Key words: Music therapy; Mechanical ventilation; Physiology; Anxiety state; Meta-analysis