Abstract
In conscious dogs, whose dorsal spinal roots (T11-L3) had been previously sectioned, adrenal venous blood was collected and analyzed for 17-hydroxycorticosteroids (17- OHCS) by the method of Nelson and Samuels. The animals, paced by an attendant on a bicycle, were run 1.2–13.1 km at speeds of 106–181 meters /min. Dogs, in which no signs of fatigue were observed during and after running, showed no definite changes in 17-OHCS secretion rate. In dogs which seemed to be somewhat tired but were notcompletely exhausted, adrenal 17-OHCS secretion rate increased only transitorily. In completely exhausted dogs adrenal 17-OHCS secretion rate increased markedly and attained 1.1– 2.1 μg/kg/min after running, while it had been less than 0.3 μg/kg/min before running. Generally speaking, increased adrenal 17-OHCS secretion is related to exhaustion but not to exercise, its duration or intensity. {Endocrinology 80: 1148, 1967)
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