Abstract
The effect of acetylcholine (ACh) on the release of 3H-norepinephrine (NE) from the cerebellum and 3H-dopamine (DA) from the striatum following the administration of potassium chloride or electrical field stimulation was studied in superfused brain slices. ACh in conc. of 10 −6 and 10 −5M significantly inhibited the release of 3H-NE from cerebellar slices and 3H-DA from striatal slices following 2 min infusion of 50mM potassium chloride. In addition ACh produced a dose-dependent inhibition of the release of 3H-DA from striatal slices following electrical stimulation. The results obtained in the present study are quite consistent with the concept that a muscarinic inhibitory mechanism may be operative on noradrenergic and dopaminergic neurons in the brain.
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