Effect of Moxibustion on Hyperhomocysteinemia and Oxidative Stress Induced by High-Methionine Diet.

Hao Wang,Zhao Baixiao,Rui He,Xin Hui,Yao Lin,Lue Ha

doi:10.1155/2020/3184785

Hao Wang, Zhao Baixiao + Show 4 more

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https://doi.org/10.1155/2020/3184785

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Abstract

Objective The aim of this study was to assess the effects of moxibustion on the animal model of oxidative stress and cardiovascular injury induced by high-methionine diet (2% methionine and 3.5% fat on the basis of ordinary maintenance feed) during 12 weeks. Methods 53 mice were divided into four groups: mice in the Control group (n = 8), mice in the Met group (n = 8), mice in the Met group (n = 8), mice in the Met group (n = 8), mice in the Met group (Results Compared with the Met group, our results indicated that through moxibustion intervention, the content of serum Hcy and its intermediate metabolite SAH can be reduced to a certain extent, and SOD, HO-1, and ox-LDL can be increased. Conclusion This study showed moxibustion's ability to enhance the body's antioxidation and protect vascular endothelial function, thus playing an early role in the prevention and treatment of atherosclerosis.

Highlights

In addition to many traditional risk factors, more and more studies have focused on the relationship between homocysteine (Hcy) and atherosclerosis (AS) [1, 2]
According to the formation mechanism of HHcy, the current expert guidelines recommend folic acid and vitamin B12 supplementation for treatment [8,9,10,11,12], but meta-analysis results show that folic acid supplementation for more than three years is necessary to reduce the risk of stroke [13]
E applied doses were selected based on the literature data which showed that moderate hyperhomocysteinemia can be achieved by increasing the total methionine content up to 12 to 20 g/kg in diet

Summary

Introduction

In addition to many traditional risk factors (such as hypertension, diabetes, hyperlipidemia, and smoking), more and more studies have focused on the relationship between homocysteine (Hcy) and atherosclerosis (AS) [1, 2]. Hyperhomocysteinemia (HHcy) is an independent risk factor for atherosclerosis [3, 4]. About 75% of the nearly 300 million hypertensive patients in China are accompanied by HHcy, and the risk of cardiovascular disease increases by 1.6–1.8 times with the increase of serum Hcy level by 5 μmol/L in a dose-dependent manner [7, 8]. According to the formation mechanism of HHcy, the current expert guidelines recommend folic acid and vitamin B12 supplementation for treatment [8,9,10,11,12], but meta-analysis results show that folic acid supplementation for more than three years is necessary to reduce the risk of stroke [13]

Methods

Results

Conclusion