Abstract
The somatosensory cortex responses and periaqueductal grey matter responses evoked by electric peripheral nerve stimulation were studied following topical application of 1% morphine solution to the primary somatosensory area of rat cerebral cortex. Cortically applied morphine increased the negative component of cortical potentials and enhanced the peak-to-peak amplitude of the periaqueductal grey responses. It is suggested that cortical excitation induced by morphine generates descending bioelectrical impulses modulating neuronal activity at this mesencephalic level.
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