Abstract
The effect of morphine on the rat striatal cholinergic system was investigated in vitro by measuring the rates of [ 3H]choline uptake and [ 3H]acetylcholine release in striatal synaptosomes after in vivo injections of morphine sulfate. Morphine caused a 50 per cent increase in the V max of [ 3H]choline uptake. Although a concomitant increase was also measured in the amount of [ 3H] acetylcholine released, it could be explained by the previous increase in uptake. It is suggested that morphine had an overall stimulatory effect on the striatal cholinergic system which may be a transynaptic phenomenon rather than a direct effect on the cholinergic cell.
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