Abstract
Fluorosis is a metabolic disease that is endemic in nearly 25 countries with India being one of the most affected. It primarily affects the bone and the teeth. Moringa oleifera (MO) leaves are known to reduce the effect of fluorosis on various tissues. Therefore, it is of interest to document the effect of Moringa oleifera leaves on the hematological profile of fluorosis affected rats. Twenty four Sprague Dawley rats were housed two per cage in a room with 12 hours light and 12 hours dark cycle. The rats were allowed to adjust to the laboratory environment for about one to two weeks before the beginning of the study. This study reveals that MO leaves is effective in reducing the plasma fluoride content. It also helps in improving the Hb % and RBC count in fluorosis affected rats. Data shows that Moringa olifera leaves powder is effective in reducing the plasma fluoride content. It also helps in improving the Hemoglobin percentage & Red Blood Cell count in fluorosis affected rats.
Highlights
Fluoride is known to act as a double edged sword and is the 13th most abundant highly reactive, electronegative halogen with an atomic number 9 in the earth’s crust [1,2]
Complete blood picture & blood smear analysis: After collecting the EDTA blood samples from all the groups, haemoglobin (Hb) (g/dL), Red blood cell count (RBC), Total leukocyte count (TLC), Packed cell volume (PCV), Differential leukocyte count (DLC) & Reticulocyte count were estimated by automated haematology system analyzer method; peripheral blood smear was studied to know the morphology of cells
There was no significant difference in other parameters such as Mean corpuscular volume (MCV), Mean Corpuscular Haemoglobin concentration (MCHC), Mean corpuscular Haemoglobin (MCH), TLC, PLT & Rets %
Summary
Declaration on Publication Ethics: The author’s state that they adhere with COPE guidelines on publishing ethics as described elsewhere at https://publicationethics.org/. The authors declare that they are not withholding any information that is misleading to the publisher in regard to this article. Effect of Moringa oleifera leaves on hematological profile of fluorosis affected rats
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