Abstract
Glutamate is one of the most exciting neurotransmitters in the brain. The current study investigates the effect of Monosodium glutamate (MSG) on Serum level of that include, glutamate, acetylcholinesterase, epinephrine and serotonin protective effect of vitamin B12. Rats were divided into five equal groups n=10, each group was further divided into two groups (A and B, n=5) and treated for 30 and 60 days, respectively. The 1st group received distilled water orally by gavage, the 2nd and 3rd group received MSG in a dose of 20, and 40 mg/kg body weight orally by gavage, respectively, the 4th and 5th groups received MSG and vitamin B12 in a dose of 20 or 40 mg MSG/kg in addition to 0.3m vitamin B12/kg, respectively. Monosodium glutamate causes a significant reduction in serum level of neurotransmitters. These changes were reversed by treatment with vitamin B12. There was improvement in the levels of neurotransmitters after treatment with vitamin B12
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