Abstract
Objective: Diabetes is a group of disorders characterized by high blood glucose levels. Disturbances in serum electrolytes like sodium (Na+) and potassium (K+) are found in diabetes. The purpose of the study was to investigate the disturbances in concentrations of serum electrolytes in hyperglycemic crisis and the effect of syzygium cumini and momordica charantia standardized aqueous extracts on serum electrolytes (Na+and K+) in normal and diabetic rats.Methods: Diabetes is induced by intraperitoneal injection of alloxan at a dose of 120 mg/kg b. w in rats. Rats were divided into 5 groups (normal control, disease control, metformin, test 1 and test 2). In test groups 1 and 2, SASESC (standardized aqueous seed extract of syzygium cumini) and SAFEMC (standardized aqueous fruit extract of momordica charantia) were respectively administered orally to alloxan induced diabetic rats, and their serum electrolyte levels were observed at 1st, 4th, 7th and 14th days.Results: By the 14thday, the Na+ and K+ levels in groups 4 and 5 were almost normal. However, in group 3 (standard), Na+levels were relatively lower and K+ levels were relatively higher than groups 4 and 5 (test). In group 2 (disease control) as compared to group 1 (normal control), a decrease in Na+ and increase in K+ levels was observed even on day 14.Conclusion: Treatment with anti diabetic drugs like metformin, syzygium cumini (test-1), momordica charantia (test-2) restored the electrolyte levels almost back to normal over a period of study (14 d). There was significant (**P<0.01, *P<0.05) normalization of electrolyte levels in diabetic rats. It was concluded that syzygium cumini and momordica charantia showed better efficiency in restoring the electrolyte imbalance as compared to metformin during our study.
Highlights
Diabetes mellitus (DM) is a group of metabolic diseases characterized by high blood glucose level resulting from defects in insulin secretion, insulin action, or both
Fig. 1&2 shows significant (**P
The current study showed a major reduction in serum Na+ and an elevation in serum K+in DM group
Summary
Diabetes mellitus (DM) is a group of metabolic diseases characterized by high blood glucose level (hyperglycemia) resulting from defects in insulin secretion, insulin action, or both. A proper balance of electrolytes such as sodium (Na+), potassium (K+), calcium (Ca2+), magnesium (Mg2+) and others are essential for overall health. They have a pivotal role in the maintenance of homeostasis inside the body, regulation of heart and brain function, body fluid balance, ventilation, pH etc [3]. DM is amongst those diseases which show frequent disturbances of electrolytes and acidbase relations, especially in patients with deranged renal function and other end-organ injury, mal-absorption syndromes, acid-base imbalances and multiple drug regimens and medications for DM management. The knowledge and insight of the disease process and its management would create the way for ‘pathophysiology-directed therapy’, leading to prevention of the several adverse effects associated with acid-base and electrolyte disorders and their management [4,5,6,7,8]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
