Abstract
Abstract Auriculaia auricula is considered as species of Mu Er in Chinese medicine and today are used interchangeably. A. auricula polysaccharides have been shown anti-cholesterol and anti-hyperglycemia. The aim of this research was to investigate the hypolipidemic and anti-hyperglycemic effects of extracts from different molecular weight fragments of A. auricula fermentation supernatant (AAFS). A. auricula was through mixed fermentation by Saccharomyces cerevisiae and Bifidobacterium. The results shown that with the molecular weight of AAFS increases, the ability to lower blood lipids and blood glucose gradually increases. In the lowering blood lipids, the AAFS of above 300 kDa has the strongest sodium bovine cholate binding capacity and sodium taurocholate binding capacity. The AAFS of 100-300 kDa has the strongest sodium glycocholateas binding capacity. In the lowering blood glucose, the AAFS of 100-300 kDa has the strongest inhibition of α-amylase and α-glucosidase activity. The AAFS of above 300 kDa has the highest index of the glucose dialysis retardation at 30min, and 60min. The AAFS of 100-300 kDa has the highest index of the glucose dialysis retardation at 90min. The study shows that the ability of hypolipidemic and anti-hyperglycemic of AAFS can change with molecular weight, and the contents of substance has changed.
Highlights
Hyperglycemia and hyperlipidemia as a result of an imbalance between peripheral insulin sensitivity and peripheral insulin sensitivity in internal and organization are a group of prevalent disease symptom which is easy to lead to diabetes (Reilly & Rader, 2003)
The mixture was fermented by Bifidobacterium and Saccharomyces cerevisiae at 30 °C for 60h to obtain the A. auricula fermentation broth
It was shown that auricula fermentation supernatant (AAFS) of have the strongest inhibition of α-amylase activity that can reach 66.74%, and there is no significant difference between 100-300 kDa and above 300 kDa (p>0.05)
Summary
Hyperglycemia and hyperlipidemia as a result of an imbalance between peripheral insulin sensitivity and peripheral insulin sensitivity in internal and organization are a group of prevalent disease symptom which is easy to lead to diabetes (Reilly & Rader, 2003). Found in study that there is a obviously relationship between diabetes and lipid prole abnormalities (Roşu et al, 2000). The standard of HDL cholesterol and increase of LDL cholesterol have relationship with high blood glucose levels and this is a reasion of increasing risk of cardiovascular disease. The hyperlipidemia is a pivotal factor of atherosclerosis, thrombus and many lipid abnormal symptom such as obesity, coronary heart disease and brain infarction and peripheral vascular disease. According to reports that high levels of cholesterol and blood lipid reduces antioxidative enzyme activities (Revenko et al, 1991). It is critical for modern person to contral their blood sugar and lipid levels in order to decreasing the risk of diabetes and cardiovascular diseases (Sudasinghe & Peiris, 2018). The effective method for reducing high blood sugar involves the supply of insulin or other drugs with decreasing blood sugar function in combine with recommendations for diet regulation and exercise training (Caprio & Fonseca, 2014)
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