Abstract
BackgroundHyaluronic acid (HA) dermal biphasic fillers are synthesized for their efficacy in correcting aesthetic defects such as wrinkles, scars and facial contouring defects. The fillers consist of crosslinked HA microspheres suspended in a noncrosslinked HA. To extend the duration of HAs within the dermis and obtain the particle texturing feel, HAs are crosslinked to obtain the suitable mechanical properties.ResultsHyaluronic acid (HA) dermal biphasic fillers are prepared by mixing the crosslinked HA microspheres and the noncrosslinked HAs. The elastic modulus of the fillers increased with raising the volume fraction of the microspheres. The mechanical properties and the particle texturing feel of the fillers made from crosslinked HA (1058 kDa) microspheres suspended in noncrosslinked HA (1368 kDa) are successfully achieved, which are adequate for the fillers.ConclusionsDermal biphasic HA fillers made from 1058 kDa exhibit suitable elastic moduli (211 to 420 Pa) and particle texturing feel (scale 7 ~ 9).
Highlights
Hyaluronic acid (HA) dermal biphasic fillers are synthesized for their efficacy in correcting aesthetic defects such as wrinkles, scars and facial contouring defects
The molecular weight (MW) of HA used for MS fabrication influenced the size of the MS
The MSs made from 697 kDa HA were larger than the MSs prepared from 1058 kDa probably due to the intramolecular crosslinking rather than the intermolecular crosslinking caused by the short length of 697 kDa HA [9]
Summary
Hyaluronic acid (HA) dermal biphasic fillers are synthesized for their efficacy in correcting aesthetic defects such as wrinkles, scars and facial contouring defects. Hyaluronic acid (HA) exhibits poor biomechanical properties as a dermal fillers due to the poor viscoelasticity and the short half-life of HA when injected into normal skin [1,2,3,4,5,6,7,8,9,10,11]. The monophasic fillers are prepared by mixing the high-molecular-weight HA and the low-molecular-weight HA. They have weak strength of gel and can transform by external force. Biphasic fillers (Restylane®, Q-Med, Sweden) consist of gel
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