Abstract
Objective Limited studies have assessed the effect of moderate-intensity continuous aerobic exercise on hepatic fat content and visceral lipids in hepatic patients with diabesity. This study was designed to evaluate hepatic fat content and visceral lipids following moderate-intensity continuous aerobic exercise in hepatic patients with diabesity. Design A single-blinded randomised controlled trial. Methods Thirty-one diabetic obese patients with nonalcoholic fatty liver disease were recruited into this study. The patients were randomly classified into exercise and control groups, fifteen patients in the exercise group and sixteen patients in the control group. The exercise group received an 8-week moderate-intensity continuous aerobic exercise program with standard medical treatment, while the control group received standard medical treatment without any exercise program. Hepatic fat content and visceral lipids were assessed before and after intervention at the end of the study. Results Baseline and clinical characteristics showed a nonsignificant difference between the two groups (p > 0.05). At the end of the intervention, the aerobic exercise showed significant improvements (serum triglycerides and low-density lipoproteins (LDLs), p ≤ 0.002, total cholesterol, p=0.004, visceral fats, p=0.016, glycated hemoglobin (HbA1C), p=0.022, high-density lipoproteins (HDLs), p=0.038, alanine transaminases (AL), p=0.044, intrahepatic triglyceride and HOMA-IR, p=0.046, and body mass index (BMI), p=0.047), while the control group showed a nonsignificant difference (p > 0.05). The postintervention analysis showed significant differences in favor of the aerobic exercise group (p < 0.05). Conclusions Moderate-intensity continuous aerobic exercise reduces the hepatic fat content and visceral lipids in hepatic patients with diabesity. Recommendations should be prescribed for encouraging moderate-intensity aerobic exercise training, particularly hepatic patients with diabesity.
Highlights
Diabesity is a modern epidemic term used to depict the combination of type 2 diabetes mellitus (T2DM) and obesity
Patients were included in the study if they were clinically diagnosed with T2DM, Obesity class II-III (BMI ≥ 35 kg/m2), and Nonalcoholic fatty liver disease (NAFLD). ey have followed in the endemic diseases, endocrine, and diabetes outpatient clinics and received their medications such as metformin, omega-3 fatty acids, and pentoxifylline
Each patient was assessed for intrahepatic triglycerides (IHTG), visceral lipids, lipid profile, insulin sensitivity, glycated hemoglobin (HbA1c), and alanine transaminases (AL) before and after intervention by the same evaluator who was blinded to the study group allocation and the aim of the study. e procedure and the nature of the study were explained for all patients before intervention
Summary
Limited studies have assessed the effect of moderate-intensity continuous aerobic exercise on hepatic fat content and visceral lipids in hepatic patients with diabesity. is study was designed to evaluate hepatic fat content and visceral lipids following moderate-intensity continuous aerobic exercise in hepatic patients with diabesity. Limited studies have assessed the effect of moderate-intensity continuous aerobic exercise on hepatic fat content and visceral lipids in hepatic patients with diabesity. Is study was designed to evaluate hepatic fat content and visceral lipids following moderate-intensity continuous aerobic exercise in hepatic patients with diabesity. Irty-one diabetic obese patients with nonalcoholic fatty liver disease were recruited into this study Methods. irty-one diabetic obese patients with nonalcoholic fatty liver disease were recruited into this study
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
