Effect of Microecological Regulator Combined with Enteral Nutrition on Immune and Coagulation Function in Patients with Chronic Critical Illness.

Abstract

This study was to investigate the effect of microecological regulators combined with enteral nutrition on immune and coagulation function in patients with a chronic critical illness. For this purpose, 78 patients with chronic critical illness in our hospital from January 2020 to January 2022 were divided into study and control groups according to a simple random number table, with 39 cases in each group. The control group was given enteral nutrition support, and the study group was given a microecological regulator. The variables of the study were the intervention effects [albumin (ALB), prealbumin (PA), serum total protein (TP)], immune function (CD3+, CD4+, CD4+/CD8+), coagulation function [platelet count (PLT), Fibrinogen (FIB), prothrombin time (PT) and the incidence of complications. Results showed that Before the intervention, ALB (30.69 ± 3.66) G/L, PA (132.91 ± 18.04) mg/L, TP (55.65 ± 5.42) G/L in the study group and ALB (31.78 ± 4.24) TP (57.01 ± 5.13) G/L had no significant difference (P>0.05). After the intervention, the levels of ALB, PA and TP in the two groups were higher than those before the intervention. ALB (38.91 ± 3.54) G/L, PA (204.24 ± 28.80) mg/L and TP (69.75 ± 7.48) G/L in the study group were higher than those in the control group (ALB 34.83 ± 3.82) TP (62.70 ± 6.33) g/L (P<0.05). There was no significant difference between CD4+/CD8+ (1.31 ± 0.39) (P>0.05). After the intervention, the levels of CD3+, CD4+, CD4 and CD8 in the two groups were higher than those before the intervention. CD3+, CD4+ and CD4+/CD8+ were higher than that of the control group. in the study group PLT (226.57 ± 41.15) × 109/L, FIB (3.58 ± 1.09) G/L, PT (9.41 ± 0.82) s were recoeded. There was no significant difference between FIB (3.71 ± 1.13) G/L and PT (9.24 ± 0.77) s (P>0.05). After the intervention, PLT and FIB decreased and PT increased in both groups. PLT (177.15 ± 12.51) × 109/L and FIB (2.57 ± 0.39) G/L in the study group were lower than PLT (198.54 ± 10.77) × 109/L and FIB (3.04 ± 0.54) PT (15.79 ± 1.21) s was higher than PT (13.13 ± 1.33) s in the control group (P<0.05). The incidence of complications in the study group (5.13%) was lower than that in the control group (20.51%) (P<0.05). The conclusion was that the intervention effect of microecological regulators combined with enteral nutrition on patients with chronic critical illness is significant, which can improve their nutritional status and immune function, improve coagulation function, and reduce the incidence of complications.