Abstract
BackgroundIron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication. Bacterial siderophores can be used to reduce free ferric ion concentration from the cellular environment.MethodsIn the present study, we have evaluated effect of three siderophores – exochelin-MS, mycobactin S and deferoxamine B on the proliferation of mammalian cell lines using MTT assay.ResultsThese siderophores caused a significant decrease in the viability of malignant cells, without significantly affecting non-malignant cells.ConclusionsBased on these results, we suggest that iron-chelation therapy could be explored as an adjunctive therapeutic option against cancer along with other therapies.
Highlights
Iron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication
Bacterial iron chelators termed siderophores can be used for reducing free iron concentration in the cellular environment
Gradient Trifluoroacetic acid-Acetonitrile (TFAACN) solvent system was used for analysis of 10 μL of 1.0 μg/mL concentration of ferrioxamine B
Summary
Iron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication. Bacterial siderophores can be used to reduce free ferric ion concentration from the cellular environment. Iron is a vital nutrient for all cells. Neoplastic cells have a higher requirement for iron than normal cells as they proliferate at a faster rate. Iron depletion by iron-chelating agents may deprive the rapidly dividing malignant cells of the DNA precursors required for replication, resulting in the inhibition of their proliferation [2, 3]. Bacterial iron chelators termed siderophores can be used for reducing free iron concentration in the cellular environment. Growing microbial cells in iron-deficient laboratory growth media allows isolation and characterization of the siderophores
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