Abstract
Objective To observe the effect of Mg-Zn alloy on the integrin expression of preosteoblasts MC3T3-E1. Methods The integrin α2, α5, β1 mRNA expression of 1.0 × 105/ml MC3T3-E1 cultured with Mg-Zn and PLLA was detected by real-time fluorescent quantitative polymerase chain reaction (PCR) after 1, 3, 6, 9, 12 and 15 days. Results The mRNA expression of integrin β1 in osteoblasts treated with Mg-Zn and PLLA was the most abundant and increased with time (P 0. 05 ); The mRNA expression of integrin α5 on MgZn was increased with time ( P 0. 05 ); The mRNA expression of integrin α2 was higher than integrin α5 on Mg-Zn except at the 15th day(P <0. 01 ). Conclusion Compared with PLLA,Mg-Zn enhanced the mRNA expression of integrin α2 and α5 of osteoblasts, which would benefit to the attachment of osteoblasts with the materials surface. Key words: Mg-Zn alloy; Osteoblast; Integrin; Adhesion
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