Abstract
This study was carried out to determine the effect of metoclopramide on the absorption of lamotrigine when the two drugs were given concurrently by the oral route in rabbits. The first group of animals was given lamotrigine (20 mg/kg, p.o.) alone and the second group was given the same dose of lamotrigine together with metoclopramide (3 mg/kg, p.o.) and plasma samples were collected at different time intervals following drug administration. The concentrations of lamotrigine in plasma were determined by using a high-performance liquid chromatographic (HPLC) method. Co-administration of lamotrigine with metoclopramide resulted in a significant increase ( P < 0.05) in the mean maximum plasma concentration ( C max), mean area under the plasma concentration-time curve (AUC) and a significant decrease ( P < 0.05) in the mean time to reach maximum concentration ( T max) as compared to those obtained for lamotrigine alone. No significant changes were observed in the elimination half-life ( t 1 2 ) of lamotrigine when it was administered together with metoclopramide. These results suggest an increase in the total absorption of lamotrigine when it is administered concurrently with metoclopramide.
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