Abstract
In dogs with gastric fistulae and vagally denervated Heidenhain pouches, metiamide, a histamine H2-receptor antagonist, infused intravenously in a dose of 12 μmoles per kg-hr, inhibited near maximal acid responses to histamine, pentagastrin, Urecholine, or a peptone meal. Atropine sulfate (0.12 μmole per kg-hr) did not significantly affect acid output induced by histamine, but was a more effective inhibitor of acid secretion stimulated by pentagastrin, Urecholine, or a peptone meal. Serum gastrin response to a peptone meal was unchanged by metiamide but partly suppressed by atropine. The inhibitory effect of metiamide was always associated with a marked reduction in mucosal blood flow. The ratio of aminopyrine concentration in the gastric juice and blood plasma was not significantly changed by metiamide, indicating that the persistent reduction in gastric mucosal blood flow was secondary to an inhibition of gastric secretion.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
