Abstract
Researchers at the National Institutes of Health, Bethesda, MD, studying the genetic and behavioral effects of methylphenidate (MPH) in juvenile male rhesus monkeys, observed after 14 mo of treatment a delay in puberty with impaired testicular descent and reduced testicular volume.
Highlights
The findings indicate that MPH administration, beginning before puberty, and with clinically relevant blood levels of the drug, impaired pubertal testicular development until -5 years of age
Deficits in testicular volume and testicular secretion resolved over the 40-month observation period, which suggests that the effect of MPH on puberty is not permanent. (Mattison DR, Plant TM, Lin HM, et al Pubertal delay in male nonhuman primates (Macaca mulatta) treated with methylphenidate
The clinician should be aware of a possible effect of stimulants on pubertal development, and management of ADHD patients with MPH and other stimulants should be monitored carefully, especially in younger children
Summary
Pretreatment ECG and/or cardiac consultation indications are suggested as follows: heart murmur, high blood pressure, palpitations, or syncope, and personal or family history of early heart disease. Researchers at the National Institutes of Health, Bethesda, MD, studying the genetic and behavioral effects of methylphenidate (MPH) in juvenile male rhesus monkeys, observed after 14 mo of treatment a delay in puberty with impaired testicular descent and reduced testicular volume. The findings indicate that MPH administration, beginning before puberty, and with clinically relevant blood levels of the drug, impaired pubertal testicular development until -5 years of age.
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