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Japanese Journal of MicrobiologyVolume 9, Issue 3 p. 123-129 ArticleFree Access EFFECT OF METHYLENE BLUE ON THE ACTION OF 4-NITROQUINOLINE N-OXIDE AND ACRIFLAVINE IN INDUCING RESPIRATION-DEFICIENT MUTANTS OF SACCHAROMYCES CEREVISIAE Tamotsu Morita, Tamotsu Morita Department of Microbiology, Shizuoka College of Pharmacy, ShizuokaSearch for more papers by this authorIchiji Mifuchi, Ichiji Mifuchi Department of Microbiology, Shizuoka College of Pharmacy, ShizuokaSearch for more papers by this author Tamotsu Morita, Tamotsu Morita Department of Microbiology, Shizuoka College of Pharmacy, ShizuokaSearch for more papers by this authorIchiji Mifuchi, Ichiji Mifuchi Department of Microbiology, Shizuoka College of Pharmacy, ShizuokaSearch for more papers by this author First published: March 1965 https://doi.org/10.1111/j.1348-0421.1965.tb00281.xCitations: 4AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat REFERENCES 1Brenner, S., L. Barnett, F. H. C. Crick, and A. Orgel. 1961. The theory of mutagenesis. J. Mol. Biol. 3: 121. 2Ephrussi, B., P. L'Heritier et H. Hottinguer. 1949. Action de acriflavine sur les levures. VI. Analyse quantitative de la transformation des populations. Ann. inst. Pasteur 77: 64. 3Gause, G. G., N. P. Loshkareva, I. B. Zbarsky, and G. F. Gause. 1964. Deoxyribonucleic acid base composition in certain bacteria and their mutants with impaired respiration. Nature 203: 598. 4Hirota, Y. 1960. The effect of acridine dyes on mating type factors in Escherichia coli. Proc. Natl. Acad. Sci. U. S. 46: 57. 5Hirota, Y. and T. Iijima. 1957. Acriflavine as an effective agent for eliminating F-factor in Escherichia coli K-12. Nature 180: 655. 6Kotani, M., F. Egami, I. Watanabe, Y. Ikeda, and F. Osawa. 1963. Bunshiseibutsugaku. 2nd. ed. Asakura Shoten, Tokyo p. 48. (in Japanese). 7Lerman, L. S. 1961. Structural considerations in the interaction of deoxyribonucleic acid and acridines. J. Mol. Biol. 3: 18. 8Lindegren, C. C., S. Nagai, and H. Nagai. 1958. Induction of respiratory deficiency in yeast by manganese, copper, cobalt and nickel. Nature 182: 446. 9Mifuchi, I., and T. Morita. 1962. Induction of the respiration deficient mutant of Saccharomyces cerevisiae with carcinogenic agent, 4-nitroquinoline N-oxide. Medicine and Biology 64: 101. (in Japanese). 10Mifuchi, I., T. Morita, Y. Yanagihara, M. Hosoi, and M. Nishida. 1963. Induction of respiration-deficient mutant of Saccharomyces cerevisiae by carcinogenic agent, 4-nitroquinoline N-oxide and the existence of toxohormone-like factor in the mutant. Japan. J. Microbiol. 7: 69. 11Mitsuhashi, S., K. Harada, and M. Kameda. 1961. Elimination of transmissible drug-resistance by treatment with acriflavine. Nature 189: 947. 12Morita, T. Unpublished data. 13Nagai, S. 1959. Induction of the respiration deficient mutation in yeast by various synthetic dyes. Science 130: 1188. 14Nagai, S. 1962. Interferences between some inducers of the respiration-deficient mutation in yeast. Exptl. Cell Res. 24: 145. 15Nagai, S. 1963. Methylene blue and toluidine blue interfering with the production of respiration-deficient mutants in yeast by acriflavine. Exptl. Cell Res. 29: 82. 16Nagai, S. 1963. Spectrophotometry of yeast cell colored alive with acriflavine and other basic dyes. Exptl. Cell Res. 31: 275. 17Nagai, S., N. Yanagishima, and H. Nagai. 1961. Advances in the study of respiration-deficient (RD) mutation in yeast and other microorganisms. Bacteriol. Rev. 25: 404. 18Nagata, C., A. Imamura, K. Fukui, and H. Saito. 1963. Quantity of charge transfer and carcinogenic activity of 4-nitroquinoline 1-oxides and of some aromatic hydrocarbons. Gann 54: 401. 19Ogur, M., and R. S. John. 1956. A differential and diagnostic plating method for population studies of respiration deficieney in yeast. J. Bacteriol. 72: 500. 20Okabayashi, T. 1955. Studies on fungistatic substances (VIII). On the mutagenic activity of 4-nitroquinoline-1-oxide. J. Fer. Tech. 33: 513. (in Japanese). 21Okabayashi, T. 1962. Mutagenic activity of 4-hydroxyaminoquinoline 1-oxide. Chem. Pharm. Bull. 10: 1127. 22Ono, T. 1964. The effects of carcinogens on the biological activity of nucleic acids. Protein Nucleic Acid Enzyme 9: 1122. (in Japanese). 23Raut, C. 1953. A cytochrome deficient mutant of Saccharomyces cerevisiae. Exptl. Cell Res. 4: 295. 24Sugimura, T. Personal communication. 25Watanabe, T., and T. Fukusawa. 1961. Episome-mediated transfer of drug resistance in Enterobacteriaceae. II. Elimination of resistance factors with acridine dyes. J. Bacteriol. 81: 679. 26Yanagishima, N. 1956. On the W variant of yeast, with special reference to its appearance and character. J. Inst. Polytech. Osaka City Univ. Ser. D. 7: 131. 27Yas, M. 1956. A hereditary cytochrome-deficiency appearing in yeast grown at an elevated temperature. Exptl. Cell Res. 10: 746. Citing Literature Volume9, Issue3March 1965Pages 123-129 ReferencesRelatedInformation

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