Effect of methanolic extract of <i> Asparagus pubescens </i> root on non-vascular smooth muscle in experimental animals

Abstract

The effect of methanolic extract of Asparagus pubescens root was investigated on non-vascular smooth muscle in experimental animals. The extract dose-dependently reduced spontaneous rhythmic contraction of rat uterine smooth muscle. It also inhibited acetylcholine, ergometrine, oxytocin, prostaglandin E2, 5-hydroxytryptamine as well as nicotine-induced contractions on rat uterine muscle. These dose-related inhibitions were statistically significant (p Keywords : Asparagus pubescens , non-vascular smooth muscle, methanolic extract, non-specific mechanism West African Journal of Pharmacology and Drug Research Vol. 21 (1&2) 2005: pp. 31-36