Abstract
Background: Cisplatin is a cytotoxic agent in cancer therapy. Nephrotoxicity is considered as a side effect of cisplatin usage. Using rate models, we studied the possible protective impact of corn-silk (CS) extract against cisplatin-induced nephrotoxicity.Materials and Methods: Thirty-five experimental rats were divided into five groups (n=7 per each group) as follow: C1: Control received distilled water only; C2: received one dose of cisplatin, and CS: received 300 mg/kg/day of CS. Both CS1 and CS2 received 200 and 300 mg/kg/day of the CS extract orally, individually, for eight consecutive days. CS1 and CS2 received a single dose of cisplatin on the first day only. The specific biochemical markers and histopathological alterations were evaluated.Result: According to our results, cisplatin administration could have induced severe degeneration in all parts of the nephron tubules and liver. Pre-treatment with CS exhibited a significant decrease in the malondialdehyde (MDA) levels as compared to the values obtained after treatment with cisplatin alone (P<0.01). Moreover, the CS extract with 200 mg dose showed significant (P<0.01) protection against the cisplatin-induced elevation of blood urea nitrogen. Further, the serum levels of alanine transaminase and aspartate transaminase were higher in the cisplatin-treated groups, when compared to the control group (P<0.05). Furthermore, the hepatic function was also improved in cisplatin-treated animals, which were pre-treated with CS.Conclusion: CS has the potential to attenuate nephrotoxicity and lipid peroxidation induced by cisplatin in rats.[GMJ.2018;7:e1258]
Highlights
Cisplatin, named as cis-diamminedichloroplatinum (II), is an anti-neoplastic bifunctional alkylating agent, belonging to the group of platinum anti-tumor compounds
The oxidative stress resulting from increased free radical generation plays a key role in the pathogenesis of cisplatin-induced nephrotoxicity
Study Groups The rats were randomly divided into five groups of seven each: C1 as the untreated control group, which received distilled water (1 ml/day) orally for eight consecutive days; group 2, the C2 received a single dose of cisplatin (5 mg/Kg, i.p.) on the first day of study
Summary
Named as cis-diamminedichloroplatinum (II), is an anti-neoplastic bifunctional (has properties of two different functional groups) alkylating agent, belonging to the group of platinum anti-tumor compounds. DNA damage and apoptosis induced by cisplatin (oxidative stress) appear to be the mechanisms by which this drug produces renal injury. The oxidative stress resulting from increased free radical generation plays a key role in the pathogenesis of cisplatin-induced nephrotoxicity. CS is known to have a wide range of pharmacological and biological activities [13]. This herb contains proteins, vitamins, carbohydrates, calcium, potassium, manganese and sodium salts, volatile oils, and steroids. CS has been shown to have beneficial effects on nephrotoxicity via the amelioration of oxidative injury [19, 20]. This study was designed to investigate the possible protective effects of CS against cisplatin-induced nephrotoxicity in rat models
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