Abstract
BackgroundThe dried root of Salvia miltiorrhiza, Salviae miltiorrhizae Radix (SR), is one of the most popular medicinal herbs in Asian countries such as China and Korea. In Asian traditional medicine, SR is considered to have a bitter flavor, be slightly cold in nature, and exert therapeutic actions in the heart and liver meridians. Thus, SR has been used to control symptoms related to cardiovascular diseases. Hyperlipidemia is recognized as the main cause of cerebrovascular and heart diseases; consequently, therapeutic strategies for hyperlipidemia have been widely studied. In this study, the effects and molecular targets of methanol extract of SR (SRme) in hyperlipidemic mice were investigated.MethodsHigh-fat diet was fed to mice to induce hyperlipidemia, and measurement of blood cholesterol and triglycerides were conducted to evaluate the effect of SRme on hyperlipidemic mice, and gene expression in mice liver was analyzed to identify key molecules which could be potential targets for developing anti-hyperlipidemic herbal medicines.ResultsThere was no significant effect on the body weight gain of hyperlipidemic mice, but the triglyceride content in blood was significantly reduced by the administration of SRme to hyperlipidemic mice. Proteins such as minichromosome maintenance (Mcm) family which play a key role in DNA replication were identified as molecular targets in the amelioration of hyperlipidemia.ConclusionsSRme ameliorated hyperlipidemia in high-fat diet fed mice by inhibiting increase of blood serum level of triglycerides. And several proteins such as Mcm proteins were deduced to be molecular targets in treating hyperlipidemia.
Highlights
The dried root of Salvia miltiorrhiza, Salviae miltiorrhizae Radix (SR), is one of the most popular medicinal herbs in Asian countries such as China and Korea
Effect on body weight A slight increase in body weight was observed in HFD mice in comparison to that of normal group (NOR) mice over the 4-week hyperlipidemia induction period, but in the additional
By using a protein network database such as STRING, we identified target proteins, including minichromosome maintenance (Mcm) proteins, which play a key role in DNA replication (Fig. 7)
Summary
The dried root of Salvia miltiorrhiza, Salviae miltiorrhizae Radix (SR), is one of the most popular medicinal herbs in Asian countries such as China and Korea. Hyperlipidemia is recognized as the main cause of cerebrovascular and heart diseases; therapeutic strategies for hyperlipidemia have been widely studied. Hyperlipidemia is recognized as a direct cause of cerebrovascular disease and heart disease; diverse therapeutic strategies for hyperlipidemia have been studied [6]. Salviae miltiorrhizae Radix (SR), the dried root of Salvia miltiorrhiza, is one of the most popularly used medicinal herbs. It has received increasing attention for the treatment and prevention of cardiovascular system disorders [9,10,11,12]. The major bioactive constituents of SR can be classified into hydrophilic components, such as
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