Abstract
The present study was included a measurements of fasting serum glucose, total protein, potassium, and calcium levels in the sera of 25 diabetic male patients suffer from chronic renal failure; their ages range were (32-75) and compared them with 25 healthy males as control group. The aim of this study was to study the effects of antidiabetic drugs on some biochemical parameters such as fasting serum glucose, serum total protein, serum potassium and calcium. The current results demonstrated a hyperkalemia in patients and this increasing of potassium is significantly (p = 0.03), but calcium level showed no significant variations ( p>0.05 ), and serum total protein was significantly decreased in patients as compared to the controls( p = 0.0002 ).
Highlights
Diabetes mellitus was considered a disease which is chronic progressive, could be diagnostics by control losing of glycaemic over time as the lose capacity of insulin-secreting pancreatic β-cells to amende for the predominant levels of insulin sensitivity [1]
All they are share some parts to the coiled oncotic pressure (COP) of the Plasma, which is essential for normal hemodynamics
Hyperkalemia that showed in our study may be due to inhibition of aldosterone, which is found in other metabolic pathways, as well as metformin inhibits aldosteroneinduced cardio fibroblast activation [30]
Summary
Diabetes mellitus was considered a disease which is chronic progressive, could be diagnostics by control losing of glycaemic over time as the lose capacity of insulin-secreting pancreatic β-cells to amende for the predominant levels of insulin sensitivity [1]. Where the mechanism of action in a first stimulation and secretatory of insulin releasing from the ß-cell of pancreas and increased of intracellular insulin receptors, in the second way reduction of serum glucagon level, and the third pathway increasing binding of insulin to receptor of target tissue cell. Which these drugs were metabolized via the liver and excreted by liver or kidney [18, 19]. This drug may be used alone or in combination with glimepiride [18]
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