Abstract

This study investigates the effects of ischaemia using reduced flow rate and metabolic inhibition by rotenone, KCN, oligomycin and DNP on contractile force and net Mg2+ efflux from the isolated perfused rat-heart. There was a significant (Student’s t-test; P 0.01)increase in net Mg2+ efflux. In contrast, perfusion with DNP, an oxidative phosphorylation uncoupler, resulted in a significant decrease in contractile force accompanied by a highly significant (increase in Mg2+ efflux. The results indicate that both ischaemia and loss of the mitochondrial proton gradient are associated with Mg2+ efflux, and a concomitant decrease in contractile force in the isolated heart.

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