Abstract
IntroductionBy rising diabetes mellitus prevalence, the prevalence of its most complication; cardiovascular disease (CVD) is also increasing. Moreover, oxidative stress has important role in pathogenesis of diabetes and its complications. We investigated relationship between total antioxidant status (TAS) and surrogate measures of subclinical atherosclerosis (SA) with glycemic status in diabetics.Methods & materialsIn a cross-sectional study, we recorded height, weight, waist circumference (WC) and blood pressure of 267 subjects. Blood samples were collected to measure fasting blood sugar (FBS), glycated hemoglobin (HbA1c), lipid profiles and TAS. The surrogate measures of SA were Carotid Intima Media Thickness (CIMT), and Ankle Brachial Index (ABI).ResultsWe found significantly lower TAS leves and ABI values and higher CIMT in diabetic patients especially in poor glycemic group. There was a nonsignificant, weak correlation between TAS, ABI and CIMT with glycemic status (r = −0.10, −0.16, and +0.09, respectively). Multivariate regression analysis showed a significant influence of increasing age and diabetes duration on worsening CIMT in poor glycemic group.ConclusionsOur study showed poor glycemic control leads to worse CIMT by increasing age and duration of diabetes. However we did not find a significan correlation between glycemic status and TAS levels. We suggest CIMT measurement along with other SA markers in poor glycemic diabetics, especially in older patients with longer duration of diabetes, to identify high risk CVD patients.
Highlights
By rising diabetes mellitus prevalence, the prevalence of its most complication; cardiovascular disease (CVD) is increasing
Our study showed poor glycemic control leads to worse Carotid Intima Media Thickness (CIMT) by increasing age and duration of diabetes
We suggest CIMT measurement along with other subclinical atherosclerosis (SA) markers in poor glycemic diabetics, especially in older patients with longer duration of diabetes, to identify high risk CVD patients
Summary
By rising diabetes mellitus prevalence, the prevalence of its most complication; cardiovascular disease (CVD) is increasing. Diabetes mellitus is a chronic hyperglycemic state associated with serious cardiometabolic abnormalities such as insulin resistance, hyperlipidemia, hypertension, and obesity. These aberrancies are almost always accompanied by oxidative stress [1]. A significant reduction in the efficiency of antioxidant defenses and/or overproduction of reactive oxygen species (ROS) [2] has a crucial role in Cardiovascular disease (CVD) is the most threatening complication of diabetes. The role of hyperglycemia as an independent risk factor for development of CVD is supported by the United Kingdom Prospective Diabetes Study (UKPDS) [6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
