Abstract
In the present work, an attempt was made to engineer a mesoporous silica coated magnetic nanoparticles (MNF@mSiO2) for twin mode contrast in magnetic resonance imaging (MRI) with reduced toxicity. Superparamagnetic manganese ferrite nanoparticles were synthesized with variable mesoporous silica shell thickness to control the water molecules interacting with metal oxide core. 178 nm was the optimum hydrodynamic diameter of mesoporous ferrite core-shell nanoparticles that showed maximum longitudinal relaxation time (T1) and transverse relaxation time (T2) in MRI due to the storage of water molecules in mesoporous silica coating. Besides the major role of mesoporous silica in controlling relaxivity, mesoporous silica shell also reduces the toxicity and enhances the bioavailability of superparamagnetic manganese ferrite nanoparticles. The in vitro toxicity assessment using HepG2 liver carcinoma cells shows that the mesoporous silica coating over ferrite nanoparticles could exert less toxicity compared to the uncoated particle.
Highlights
In the present work, an attempt was made to engineer a mesoporous silica coated magnetic nanoparticles (MNF@mSiO2) for twin mode contrast in magnetic resonance imaging (MRI) with reduced toxicity
Research interests have grown in developing contrast agents with dual mode Magnetic resonance (MR) imaging i.e. T1 and T2 contrast imaging with single imaging agent
Our previous study focused on the optimization of manganese doped iron oxide nanoparticles entrapped in dendrimers for dual contrasting role in MR imaging[10]
Summary
Received: 31 May 2017 Accepted: 30 August 2017 Published online: 11 September 2017. Palani Sharmiladevi[1], Viswanathan Haribabu[1], Koyeli Girigoswami[1], Abubacker Sulaiman Farook2 & Agnishwar Girigoswami 1. Superparamagnetic manganese ferrite nanoparticles were synthesized with variable mesoporous silica shell thickness to control the water molecules interacting with metal oxide core. 178 nm was the optimum hydrodynamic diameter of mesoporous ferrite core-shell nanoparticles that showed maximum longitudinal relaxation time (T1) and transverse relaxation time (T2) in MRI due to the storage of water molecules in mesoporous silica coating. A very well-known class of T1 contrast agents are gadolinium chelate complexes which interact with the water molecules thereby increasing the T1 relaxivity[4] This increase in T1 relaxivity leads to enhanced MR signal in a T1 weighted image. T1 shortening agents such as gadolinium and manganese can be doped with T2 shortening agent such as iron oxide nanoparticles using simple chemical routes, like co-precipitation method This core-shell structure of magnetic nanoparticle shows superparamagnetic nature thereby enhancing image contrast in both T1 and T2 images[9]. This variation in MR relaxivity due to mesoporous silica shell in turn will enhance MR image contrast in both T1 and T2 MR images
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