Abstract
Treatment with an aqueous extract of the aerial parts of Melothria maderaspatana, before or after CCl 4 administration in rats markedly decreased CCl 4-mediated reductions in aniline hydroxylase and p-aminopyrine N-demethylase activities. Phenobarbital-induced sleeping time in rats and kinetic enzyme studies showed that the effect of the plant was neither due to an induction of the drug metabolizing enzymes nor due to an alteration in the K m values of the enzymes.
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